This quilt is all about the fabric!
The large squares are approximately 12-1/2in square, so it is fine to use fat quarters. If you have a large print that is quite varied, you may be able to cut more than one block from it. In that case, you will want to buy yardage to allow for fussy cutting. Also, you may prefer to repeat fabrics, such as a scenic print, to allow more of it to be seen.

Finished Size: 53x71